neutropenia
Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria, bacterial fragments and immunoglobulin-bound viruses in the blood. People with neutropenia are more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening (neutropenic sepsis).
Key facts
- Medical condition (new).name
- Neutropenia
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- Neutropenia.JPG
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- Blood film with a striking absence of neutrophils, leaving only red blood cells and platelets
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- Infectious disease, Hematology
- Medical condition (new).causes
- Aplastic anemia, Glycogen storage disease, vitamin B12 and folate deficiencies, Cohen syndrome, gene mutations
- Medical condition (new).diagnosis
- CBC
- Medical condition (new).treatment
- Antibiotics, Splenectomy if needed, G-CSF
via Wikipedia infobox
Research
81,552 papers- How I investigate neutropenia.International journal of laboratory hematology · 2020
- [Leukopenia/neutropenia].
Article
11 sectionsContents
- Signs and symptoms
- Causes
- Pathophysiology
- Diagnosis
- Classification
- Treatment
- Prognosis
- Epidemiology
- See also
- References
- External links
Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria, bacterial fragments and immunoglobulin-bound viruses in the blood. People with neutropenia are more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening (neutropenic sepsis).
Neutropenia can be divided into congenital and acquired, with severe congenital neutropenia (SCN) and cyclic neutropenia (CyN) being autosomal dominant and mostly caused by heterozygous mutations in the ELANE gene (neutrophil elastase). Neutropenia can be acute (temporary) or chronic (long lasting). The term is sometimes used interchangeably with "leukopenia" ("deficit in the number of white blood cells").