Structure via PubChem · Public domain (PubChem)
nevirapine
Sign in to saveAlso known as Viramune Xr, NEV, NVP, 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b, 2',3'-e)(1,4)diazepin-6-one, BIRG-0587, 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
Nevirapine (NVP), sold under the brand name Viramune among others, is a medication used to treat and prevent HIV/AIDS, specifically HIV-1. It is generally recommended for use with other antiretroviral medications. It may be used to prevent mother to child spread during birth but is not recommended following other exposures. It is taken by mouth.
Key facts
- Drug.N
- 4
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462259855
- Drug.IUPAC_name
- 11-cyclopropyl-4-methyl-5,11-dihydro-6H- dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
- Drug.image
- Nevirapine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Nevirapine 3D balls 1fkp.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Viramune
- Drug.MedlinePlus
- a600035
- Drug.DailyMedID
- Nevirapine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AG01
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C15H14N4O
- Molecular weight
- 266.3 g/mol
- IUPAC name
- 2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
- SMILES
- CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
- InChIKey
- NQDJXKOVJZTUJA-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 58.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
5,083 papers- Nevirapine hypersensitivity.Handbook of experimental pharmacology · 2010
- Nevirapine in the treatment of HIV.Expert review of anti-infective therapy · 2004
- Nevirapine toxicity.International journal of STD & AIDS · 2006
- Nevirapine: a review of its use in the prevention and treatment of paediatric HIV infection.Paediatric drugs · 2000
- Nevirapine: pharmacokinetic considerations in children and pregnant women.Clinical pharmacokinetics · 2000
via PubMed
~11 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Preventing mother-to-child transmission
- Nonoccupational Post-Exposure Prophylaxis
- Adverse effects
- Drug interactions
- Mechanism of action
- History
- Society and culture
- References
Nevirapine (NVP), sold under the brand name Viramune among others, is a medication used to treat and prevent HIV/AIDS, specifically HIV-1. It is generally recommended for use with other antiretroviral medications. It may be used to prevent mother to child spread during birth but is not recommended following other exposures. It is taken by mouth.
Common side effects include rash, headache, nausea, feeling tired, and liver problems. The liver problems and skin rash may be severe and should be checked for during the first few months of treatment. It appears to be safe for use during pregnancy. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by blocking the function of reverse transcriptase.
Excerpted from Wikipedia’s “nevirapine” article, available under the CC BY-SA 4.0 licence.