Structure via PubChem · Public domain (PubChem)
rimexolone
Sign in to saveAlso known as Vexol
Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. It is marketed as a 1% eye drop suspension under the trade name Vexol by Alcon Laboratories, but was discontinued in the US and other countries.
Chemical data
- Formula
- C24H34O3
- Molecular weight
- 370.5 g/mol
- IUPAC name
- (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
- SMILES
- CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
- InChIKey
- QTTRZHGPGKRAFB-OOKHYKNYSA-N
- XLogP
- 3.5
- Polar surface area
- 54.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1994
- Admin. routes
- topical
- Indications
- eye inflammation, dry eye syndrome
via ChEMBL · EBI
Research
54 papers- Rimexolone.2006
- Rimexolone-induced intraocular pressure elevation.Eye (London, England) · 2001
- PMID 18031088BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1997
- Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells.Immunology letters · 2010
- Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids.Archives of ophthalmology (Chicago, Ill. : 1960) · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 370.250795
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₄H₃₄O₃
- medical condition treated
- inflammation
- canonical SMILES
- CCC(=O)C1(C(CC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C)C
- isomeric SMILES
- CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
- defined daily dose
- 20
- NCI Thesaurus ID
- C47705
- subject has role
- glucocorticoid
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- References
Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. It is marketed as a 1% eye drop suspension under the trade name Vexol by Alcon Laboratories, but was discontinued in the US and other countries.
==Medical uses== Rimexolone is used to treat inflammation after eye surgery, to treat anterior uveitis, conjunctivitis and keratitis.
Excerpted from Wikipedia’s “rimexolone” article, available under the CC BY-SA 4.0 licence.