EntityQ411582· pop 21· linked from 49 articles

nifurtimox

Nifurtimox, sold under the brand name Lampit, is a medication used to treat Chagas disease and sleeping sickness. For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. In Chagas disease it is a second-line option to benznidazole. It is given by mouth.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 462260534
Drug.image: Nifurtimox.svg
Drug.image_class: skin-invert-image
Drug.width: 250px
Drug.image2: Nifurtimox 3D.png
Drug.image_class2: bg-transparent
Drug.width2: 220px
Drug.chirality: Racemic mixture
Drug.tradename: Lampit
Drug.DailyMedID: Nifurtimox
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: P01
Drug.ATC_suffix: CC01
Drug.legal_US: Rx-only
Drug.legal_status: Rx-only
Drug.bioavailability: Low

via Wikipedia infobox

Research

1,207 papers

Nifurtimox.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2020
Update on nifurtimox for treatment of Chagas disease.Drugs of today (Barcelona, Spain : 1998) · 2021
Chagas Disease.Annals of internal medicine · 2023
Selected Aspects of the Analytical and Pharmaceutical Profiles of Nifurtimox.Journal of pharmaceutical sciences · 2023
Nifurtimox (Lampit) for Chagas disease.The Medical letter on drugs and therapeutics · 2024

via PubMed

Article

11 sections

Contents

Medical uses
Pregnancy and breastfeeding
Side effects
Contraindications
Mechanism of action
Society and culture
Legal status
Names
Research
References
External links

Common side effects include abdominal pain, headache, nausea, and weight loss. There are concerns from animal studies that it may increase the risk of cancer but these concerns have not been found in human trials. Nifurtimox is not recommended in pregnancy or in those with significant kidney or liver problems. It is a type of nitrofuran.