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Nitric oxide synthase 3
Sign in to saveAlso known as nitric oxide synthase 3 transcript variant eNOS-delta21, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, Nitric Oxide Synthase Type III, NOS type III, eNOS, EC-NOS, endothelial NOS
mammalian protein found in Homo sapiens
Protein · UniProt
Nitric oxide synthase 3
- Gene
- NOS3
- Organism
- Homo sapiens (Human)
- Length
- 1,203 aa
- Molecular mass
- 133,275 Da
- Evidence
- 1: Evidence at protein level
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
3D-structureAlternative splicingCalciumCalmodulin-bindingCell membraneCytoplasmCytoskeletonDirect protein sequencing
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
4,572 papers- Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism.F1000Research · 2020
- The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer's disease risk: a meta-analysis.Scientific reports · 2015
- The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: A systematic review and meta-analysis.Nitric oxide : biology and chemistry · 2025
- Nitric oxide synthase 3 gene variants and colorectal cancer: a meta-analysis.Asian Pacific journal of cancer prevention : APJCP · 2014
- Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis.Scientific reports · 2016
via PubMed
Clinical Trials
18 registered- PHASE2ACTIVE_NOT_RECRUITING9-ING-41 Plus Carboplatin in Salivary Gland CarcinomaGlenn J. Hanna · NCT05010629
- UNKNOWNSelective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in KazakhstanWest Kazakhstan Medical University · NCT05910151
- NAUNKNOWNFat and Sugar Metabolism During Exercise in Patients With Metabolic MyopathyRigshospitalet, Denmark · NCT02635269
- PHASE2WITHDRAWN9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland CarcinomaActuate Therapeutics Inc. · NCT04832438
- PHASE3RECRUITINGA Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care TreatmentTravere Therapeutics, Inc. · NCT06247085
- NACOMPLETEDThe Impact of Fish-oil Fatty Acids on Postprandial Vascular ReactivityUniversity of East Anglia · NCT01692431
Wikidata facts
- Instance of
- protein
- Subclass of
- nitric oxide synthase
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P29474
- physically interacts with
- nitroarginine
Sources (3)
via Wikidata · CC0