olsalazine
Sign in to saveAlso known as SID50125747, Dipentum
Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum.
Research
315 papers- Olsalazine.2006
- Evolution of olsalazine.Scandinavian journal of gastroenterology. Supplement · 1988
- Pharmacology of olsalazine.Scandinavian journal of gastroenterology. Supplement · 1988
- Olsalazine pretreatment augments chemosensitivity of gemcitabine in hepatocellular carcinoma.Journal of biochemical and molecular toxicology · 2024
- Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease.Drugs · 1991
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Wikidata facts
- Mass
- 302.05388603999995
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₄H₁₀N₂O₆
- canonical SMILES
- OC(=O)c1cc(ccc1O)N=Nc2ccc(O)c(c2)C(=O)O
- medical condition treated
- ulcerative colitis
- defined daily dose
- 1
- NCI Thesaurus ID
- C1176
- Commons category
- Olsalazine
- significant drug interaction
- azathioprine
- isomeric SMILES
- O=C(O)c1cc(/N=N/c2ccc(O)c(C(=O)O)c2)ccc1O
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Encyclopedic overview
4 sectionsContents
- History
- Supply
- Research
- References
Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum.
Olsalazine itself is a prodrug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.
Excerpted from Wikipedia’s “olsalazine” article, available under the CC BY-SA 4.0 licence.
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