Structure via PubChem · Public domain (PubChem)
ozanimod
Sign in to saveAlso known as RPC-1063, RPC1063
Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis and ulcerative colitis. It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation.
Chemical data
- Formula
- C23H24N4O3
- Molecular weight
- 404.5 g/mol
- IUPAC name
- 5-[3-[(1S)-1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxybenzonitrile
- SMILES
- CC(C)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=C4CC[C@@H](C4=CC=C3)NCCO)C#N
- InChIKey
- XRVDGNKRPOAQTN-FQEVSTJZSA-N
- XLogP
- 3.1
- Polar surface area
- 104 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2020
- Admin. routes
- oral
- Indications
- Crohn's disease, ulcerative colitis, liver disease, COVID-19
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 404.184841
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₃H₂₄N₄O₃
- canonical SMILES
- CC(C)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=C4CCC(C4=CC=C3)NCCO)C#N
- isomeric SMILES
- CC(C)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=C4CC[C@@H](C4=CC=C3)NCCO)C#N
- Commons category
- Ozanimod
via Wikidata · CC0
~12 min read
Encyclopedic overview
15 sectionsContents
- Medical uses
- Pharmacology
- Potency and selectivity
- Mechanism of action, pharmacodynamics
- Pharmacokinetics
- History
- Clinical trials
- Touchstone
- Radiance
- Sunbeam
- Society and culture
- Commercial
- Research
- References
- External links
{{Infobox drug | image = Ozanimod.svg | image_class = skin-invert-image | width = 285 | alt = | image2 = Ozanimod ball-and-stick model.png | image_class2 = bg-transparent | width2 = | alt2 = | caption =
| pronounce = | tradename = Zeposia | Drugs.com = | MedlinePlus = a620029 | licence_CA = | licence_EU = yes | DailyMedID = Ozanimod | licence_US = | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = L04 | ATC_suffix = AE02 | ATC_supplemental =
Excerpted from Wikipedia’s “ozanimod” article, available under the CC BY-SA 4.0 licence.