pharmacometrics
Sign in to savePharmacometrics is a field of study of the methodology and application of models for disease and pharmacological measurement. It uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects. It is normally applied to quantify drug, disease and trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients.
~8 min read
Encyclopedic overview
14 sectionsContents
- Origins
- Types of models
- Pharmacokinetics (PK)
- Pharmacodynamics (PD)
- Physiologically based Pharmacokinetics
- Exposure-response
- Drug-Drug Interaction
- Disease progression
- Systems Pharmacology
- Mechanistic Models
- Trial
- Organizations
- Journals
- References
Pharmacometrics is a field of study of the methodology and application of models for disease and pharmacological measurement. It uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects. It is normally applied to quantify drug, disease and trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients.
Pharmacometrics uses models based on pharmacology, physiology, and disease for quantitative analysis of interactions between drugs and patients. This involves Systems pharmacology, pharmacokinetics, pharmacodynamics and disease progression with a focus on populations and variability.
Excerpted from Wikipedia’s “pharmacometrics” article, available under the CC BY-SA 4.0 licence.