Structure via PubChem · Public domain (PubChem)
Also known as 4,9,12beta,13,20-pentahydroxytiglia-1,6-dien-3-one, 4,9,12beta,13,20-pentahydroxy-1,6-tigliadien-3-on
化合物
Chemical data
- Formula
- C20H28O6
- Molecular weight
- 364.4 g/mol
- IUPAC name
- (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one
- SMILES
- C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)O)O
- InChIKey
- QGVLYPPODPLXMB-UBTYZVCOSA-N
- XLogP
- -0.8
- Polar surface area
- 118 Ų
- H-bond donors
- 5
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 364.188589
Show 10 more facts
- chemical formula
- C₂₀H₂₈O₆
- flash point
- 313.8
- decomposition point
- 250
- canonical SMILES
- CC1C(C2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)O)O
- isomeric SMILES
- C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)O)O
- subject has role
- carcinogen
- found in taxon
- Rehmannia glutinosa
- Commons category
- Phorbols
- density
- 1.415
- refractive index
- 1.648
via Wikidata · CC0
Article · 中文
佛波酯（phorbol esters）是一类能促進腫瘤生長的有机化合物，有時會被使用在生物學實驗當中，作為二酰甘油的类似物，激活蛋白激酶C（protein kinase c）。由于佛波酯很难被代谢掉，因此这种激活作用是持续性的，将最终导致细胞的癌变。 佛波醇-12-十四烷酰-13-乙酸酯（phorbol myristoyl acetate；PMA）是其中較常見的一種。
Abstract from DBpedia / Wikipedia · CC BY-SA