Gene data
PLCB2- Name
- phospholipase C beta 2
- Type
- protein-coding
- Position
- 40,278,176–40,307,965 (−)
- Aliases
- PLC-beta-2
- Ensembl
- ENSG00000137841
- RefSeq RNA
- NM_001284297.2, NM_001284298.2, NM_001284299.2, NM_004573.3, XM_017022314.3
- RefSeq protein
- NP_001271226.1, NP_001271227.1, NP_001271228.1, NP_004564.2, XP_016877803.1
The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].
Gene Ontology
Biological process
detection of chemical stimulus involved in sensory perception of bitter tastelipid metabolic processphospholipid metabolic processsignal transductionG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathway
Molecular function
phosphatidylinositol-4,5-bisphosphate phospholipase C activityphosphatidylinositol-4,5-bisphosphate phospholipase C activityphosphatidylinositol-4,5-bisphosphate phospholipase C activityphosphatidylinositol-4,5-bisphosphate phospholipase C activityphosphatidylinositol-4,5-bisphosphate phospholipase C activityC-type glycerophospholipase activityC-type glycerophospholipase activitycalcium ion binding
Pathways
Inositol phosphate metabolism - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
phospholipase C beta 2
- Symbol
- PLCB2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:40,278,176-40,307,965
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PLCB2 PDB 2fju.png
Show 7 more facts
- HomoloGene ID
- 20957
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5330
- genomic end
- 40600136
- genomic start
- 40570377
- chromosome
- human chromosome 15
- cytogenetic location
- 15q15.1
Sources (4)
via Wikidata · CC0