PLCB2

Also known as PLC-beta-2, phospholipase C beta 2

gen de la especie Homo sapiens

Gene data

PLCB2

Name: phospholipase C beta 2
Type: protein-coding
Position: 40,278,176–40,307,965 (−)
Aliases: PLC-beta-2
Ensembl: ENSG00000137841
RefSeq RNA: NM_001284297.2, NM_001284298.2, NM_001284299.2, NM_004573.3, XM_017022314.3
RefSeq protein: NP_001271226.1, NP_001271227.1, NP_001271228.1, NP_004564.2, XP_016877803.1

The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].

Gene Ontology

Biological process

detection of chemical stimulus involved in sensory perception of bitter taste lipid metabolic process phospholipid metabolic process signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular function

phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity C-type glycerophospholipase activity C-type glycerophospholipase activity calcium ion binding

Cellular component

cytoplasm cytoplasm cytosol G-protein beta/gamma-subunit complex neuronal dense core vesicle

Pathways

via MyGene.info

Gene · Ensembl

phospholipase C beta 2

Symbol: PLCB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:40,278,176-40,307,965
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein PLCB2 PDB 2fju.png

Show 7 more facts

HomoloGene ID: 20957
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5330
genomic end: 40600136
genomic start: 40570377
chromosome: human chromosome 15
cytogenetic location: 15q15.1

Sources (4)

via Wikidata · CC0

Article · Español

La fosfoinosítido fosfolipasa C beta 2 (PLCB2) (EC 3.1.4.11) es una isozima humana de la enzima fosfoinosítido fosfolipasa C. Cataliza la reacción: 1-fosfatidil-1D-mio-inositol 4,5-bisfosfato + H2O 1D-mio-inositol-1,4,5-trisfosfato + diacilglicerol Tiene como función la producción de las moléculas mensajeras diacilglicerol e inositol 1,4,5-trifosfato. Utiliza como cofactor calcio. Interacciona con la RAC1. La activación de la PLCB1 mediada por receptor se produce de la forma más efectiva a través de la subunidad alfa-16 de la proteína G. Contiene un dominio tipo C2, un dominio tipo PI-PLC X-box y un dominio PI-PLC Y-box.

Abstract from DBpedia / Wikipedia · CC BY-SA