プレリキサフォル

Also known as AMD 3100, AMD3100, bicyclam JM-2987, JM 3100, Mozobil®

Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED, which was subsequently bought by Genzyme.

Chemical data

Formula: C28H54N8
Molecular weight: 502.8 g/mol
IUPAC name: 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
SMILES: C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
InChIKey: YIQPUIGJQJDJOS-UHFFFAOYSA-N
XLogP: 0
Polar surface area: 78.7 Å²
H-bond donors: 6
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2008
Admin. routes: parenteral
Indications: acute graft vs. host disease, multiple myeloma, acute myeloid leukemia, lymphoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 502.447
Has use: medication

Show 6 more facts

chemical formula: C₂₈H₅₄N₈
canonical SMILES: C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
defined daily dose: 16.8
medical condition treated: multiple myeloma
physically interacts with: C-X-C motif chemokine receptor 4
Commons category: Plerixafor

Sources (7)

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via Wikidata sitelinks · CC0