Peptidase M20 domain containing 1 is a circulating enzyme which in humans is encoded by the PM20D1 gene. PM20D1 regulates bioactive N-acyl amide lipids and has been implicated in obesity, type 2 diabetes, pain, and Alzheimer's disease.
Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; cellular amide catabolic process; and negative regulation of neuron death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Peptidase M20 domain containing 1 is a circulating enzyme which in humans is encoded by the PM20D1 gene. PM20D1 regulates bioactive N-acyl amide lipids and has been implicated in obesity, type 2 diabetes, pain, and Alzheimer's disease.
== Function == PM20D1 catalyzes the biosynthesis of N-fatty acyl amino acids from free fatty acids and free amino acids. Consequently PM20D1 is involved in the generation of potent bioactive lipid metabolites from two abundant cellular energy precursors.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).