RHBDF2
Sign in to saveAlso known as RHBDL5, RHBDL6, TOC, TOCG, TEC, iRhom2, rhomboid 5 homolog 2
Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene. The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.
In the Vinony graph
Vinony's link graph records 5 inbound references to RHBDF2, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Vinony links it to 5 Wikipedia language editions.
Gene data
RHBDF2- Name
- rhomboid 5 homolog 2
- Type
- protein-coding
- Position
- 76,470,884–76,501,790 (−)
- Aliases
- RHBDL5, RHBDL6, TOC, TOCG, iRhom2
- Ensembl
- ENSG00000129667
- RefSeq RNA
- NM_001005498.4, NM_001376228.1, NM_001376229.1, NM_001376230.1, NM_024599.5
- RefSeq protein
- NP_001005498.2, NP_001363157.1, NP_001363158.1, NP_001363159.1, NP_078875.4
Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
rhomboid 5 homolog 2
- Symbol
- RHBDF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:76,470,884-76,501,790
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 11612
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79651
- genomic end
- 74497872
- genomic start
- 74466973
- chromosome
- human chromosome 17
- cytogenetic location
- 17q25.1
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene. The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.
The RHBDF2 gene is located on the long arm of chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kilodaltons.
Excerpted from Wikipedia’s “RHBDF2” article, available under the CC BY-SA 4.0 licence.