POLD4
Sign in to saveAlso known as POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit
DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.
Gene data
POLD4- Name
- DNA polymerase delta 4, accessory subunit
- Type
- protein-coding
- Position
- 67,345,400–67,356,972 (−)
- Aliases
- POLDS, p12
- Ensembl
- ENSG00000175482
- RefSeq RNA
- NM_001256870.2, NM_021173.5, NR_046411.2, NR_046412.2, NR_046413.1
- RefSeq protein
- NP_001243799.1, NP_066996.3
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DNA polymerase delta 4, accessory subunit
- Symbol
- POLD4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:67,345,400-67,356,972
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10909
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57804
- genomic end
- 67124443
- genomic start
- 67350772
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.2
- expressed in
- right coronary artery
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.
==References==
Excerpted from Wikipedia’s “POLD4” article, available under the CC BY-SA 4.0 licence.
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