POLD4

Also known as POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

Gene data

POLD4

Name: DNA polymerase delta 4, accessory subunit
Type: protein-coding
Position: 67,350,772–67,356,972 (−)
Aliases: POLDS, p12
Ensembl: ENSG00000175482
RefSeq RNA: NM_001256870.2, NM_021173.5, NR_046411.2, NR_046412.2, NR_046413.1
RefSeq protein: NP_001243799.1, NP_066996.3

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

Gene Ontology

Biological process

DNA synthesis involved in DNA repair DNA synthesis involved in DNA repair DNA replication DNA-templated DNA replication DNA-templated DNA replication DNA-templated DNA replication

Molecular function

DNA-directed DNA polymerase activity protein binding

Cellular component

nucleus nucleoplasm delta DNA polymerase complex

Pathways

DNA replication - Homo sapiens (human)Base excision repair - Homo sapiens (human)Nucleotide excision repair - Homo sapiens (human)Mismatch repair - Homo sapiens (human)Homologous recombination - Homo sapiens (human)Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Recognition of DNA damage by PCNA-containing replication complex Resolution of AP sites via the multiple-nucleotide patch replacement pathway Telomere Maintenance Cell Cycle

via MyGene.info

Gene · Ensembl

DNA polymerase delta 4, accessory subunit

Symbol: POLD4
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:67,345,400-67,356,972
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 10909
exact match: identifiers.org/ncbigene/57804
genomic end: 67124443
genomic start: 67350772
cytogenetic location: 11q13.2

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Further reading

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

==References==