polymyxin B

Chemical data

Formula

C56H98N16O13

Molecular weight

1203.5 g/mol

IUPAC name

N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide

SMILES

CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O

InChIKey

WQVJHHACXVLGBL-UHFFFAOYSA-N

XLogP

-2.5

Polar surface area

491 Ų

H-bond donors

18

H-bond acceptors

18

Formal charge

0

via PubChem

• Clinical Use of Polymyxin B.Advances in experimental medicine and biology · 2019
• Polymyxin B versus colistin: an update.Expert review of anti-infective therapy · 2015
• Polymyxin B and silver nanoparticles: a nanotechnology-driven approach to overcome antibiotic resistance.Drug development and industrial pharmacy · 2025
• Polymyxin B accelerates the α-synuclein aggregation.Biophysical chemistry · 2021
• Polymyxin B hemoperfusion: a mechanistic perspective.Critical care (London, England) · 2014

via PubMed