polymyxins
Sign in to saveAlso known as Polymyxin
class=skin-invert-image|thumb|Colistin class=skin-invert-image|thumb|Polymyxin B (R=H is polymyxin B2, R=CH3 is polymyxin B1) Polymyxins are antibiotics. Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. They work mostly by breaking up the bacterial cell membrane. They are part of a broader class of molecules called nonribosomal peptides.
Research
17,949 papers- Rescuing the Last-Line Polymyxins: Achievements and Challenges.Pharmacological reviews · 2021
- Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.Clinical microbiology reviews · 2017
- Bioanalysis and Stability of Polymyxins.Advances in experimental medicine and biology · 2019
- Intravenous polymyxins: Revival with puzzle.Bioscience trends · 2017
- Polymyxins and their novel derivatives.Current opinion in microbiology · 2010
via PubMed
Wikidata facts
- Subclass of
- cyclic peptide
Show 3 more facts
- topic's main category
- Category:Polymyxin antibiotics
- subject has role
- antibiotic
- Commons category
- Polymyxins
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
8 sectionsContents
- Medical use
- Mechanism of action
- Chemistry
- Biosynthesis
- Research
- Compound mixtures in Polymyxin B drug
- See also
- References
class=skin-invert-image|thumb|Colistin class=skin-invert-image|thumb|Polymyxin B (R=H is polymyxin B2, R=CH3 is polymyxin B1) Polymyxins are antibiotics. Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. They work mostly by breaking up the bacterial cell membrane. They are part of a broader class of molecules called nonribosomal peptides.
They are produced in nature by Gram-positive bacteria such as Paenibacillus polymyxa.
Excerpted from Wikipedia’s “polymyxins” article, available under the CC BY-SA 4.0 licence.