Structure via PubChem · Public domain (PubChem)
Polyhexanide
Sign in to saveAlso known as polyhexamethylene biguanide
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under various brand names. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae. Polihexanide, sold under the brand name Akantior is a medication used for the treatment of Acanthamoeba keratitis.
Chemical data
- Formula
- C8H19N5
- Molecular weight
- 185.27 g/mol
- IUPAC name
- 1-(diaminomethylidene)-2-hexylguanidine
- SMILES
- CCCCCCN=C(N)N=C(N)N
- InChIKey
- VAZJLPXFVQHDFB-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 103 Ų
- H-bond donors
- 3
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
796 papers- Could polyhexanide and chlorine dioxide be used as an alternative to chlorhexidine? A systematic review.Sao Paulo medical journal = Revista paulista de medicina · 2022
- Polyhexanide - safety and efficacy as an antiseptic.Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2016
- Clinical use of 0.1% polyhexanide and propylbetaine on acute and hard-to-heal wounds: a literature review.Journal of wound care · 2024
- Wound bed preparation: a case series using polyhexanide and betaine solution and gel-a UK perspective.Journal of wound care · 2020
- Polyhexanide based contact lens storage fluids frequently exhibit insufficient antifungal activity against Fusarium species.International journal of medical microbiology : IJMM · 2024
via PubMed
Wikidata facts
- Instance of
- polymer
- Image
- Polyhexanide.svg
Show 3 more facts
- subject has role
- disinfectant
- medical condition treated
- skin disease
- CXSMILES
- [*]NC(=N)NC(=N)NCCCCCC[*] |Sg:n:1,2,3,4,5,6,7,8,9,10,11,12,13::ht|
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Use in ''Acanthamoeba'' keratitis treatment
- Legal status
- Safety
- Name controversy
- References
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under various brand names. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae. Polihexanide, sold under the brand name Akantior is a medication used for the treatment of Acanthamoeba keratitis.
Products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection. PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Excerpted from Wikipedia’s “Polyhexanide” article, available under the CC BY-SA 4.0 licence.