POU4F3

Also known as BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene. It's a member of BRN-3 group, also known as POU family class 4.

Gene data

POU4F3

Name: POU class 4 homeobox 3
Type: protein-coding
Position: 146,338,648–146,341,728 (+)
Aliases: BRN3C, DFNA15, DFNA42, DFNA52
Ensembl: ENSG00000091010
RefSeq RNA: NM_002700.3
RefSeq protein: NP_002691.1

This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II visual perception sensory perception of sound positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleoplasm cytoplasm cytoplasm RNA polymerase II transcription regulator complex

via MyGene.info

Wikidata facts

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exact match: identifiers.org/ncbigene/5459
HomoloGene ID: 2023
genomic end: 146341728
genomic start: 146338839
cytogenetic location: 5q32

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POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene. It's a member of BRN-3 group, also known as POU family class 4.

==Nomenclature== DFNA15 refers to a type of nonsyndromic deafness, with autosomal dominant inheritance.