PPARγ

Also known as CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5

protein-coding gene in the species Homo sapiens

Gene data

PPARG

Name: peroxisome proliferator activated receptor gamma
Type: protein-coding
Position: 12,287,368–12,455,622 (+)
Aliases: CIMT1, FPLD3, GLM1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma
Ensembl: ENSG00000132170
RefSeq RNA: NM_001330615.4, NM_001354666.3, NM_001354667.3, NM_001354668.2, NM_001354669.2
RefSeq protein: NP_001317544.2, NP_001341595.2, NP_001341596.2, NP_001341597.1, NP_001341598.1

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II placenta development regulation of DNA-templated transcription regulation of transcription by RNA polymerase II G protein-coupled receptor signaling pathway response to nutrient

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleus nucleus nucleus

Pathways

PPAR signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Thyroid cancer - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

peroxisome proliferator activated receptor gamma

Symbol: PPARG
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:12,287,368-12,455,622
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PPARG.png

Show 10 more facts

HomoloGene ID: 7899
genetic association: diabetes
genomic start: 12287368
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5468
genomic end: 12475855
chromosome: human chromosome 3
cytogenetic location: 3p25.2
expressed in: Achilles tendon
Commons category: Peroxisome proliferator activated receptor gamma, PPAR-gamma

Sources (6)

via Wikidata · CC0

Article · 日本語

PPARγ（ピーピーエイアールガンマ、Peroxisome Proliferator-Activated Receptor γ, NR1C3）とは核内受容体スーパーファミリーに属するタンパク質であり、転写因子としても機能する。「ペルオキシソーム増殖因子活性化受容体γ（ガンマ）」と和訳されることもある。PPARはα、β/δ、γの3種類のサブタイプが存在し、その中でもPPARγにはPPARγ1とγ2、γ3の少なくとも3種類のアイソフォームが存在することが知られている。選択的スプライシングの産物であるこれらのアイソフォームはそれぞれ発現や分子構造が異なる。PPARγは主に脂肪組織に分布して脂肪細胞分化などに関与するほか、マクロファージや血管内皮細胞などにも発現が見られる。インスリン抵抗性改善薬の標的分子でもある。

Abstract from DBpedia / Wikipedia · CC BY-SA

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