PRICKLE1
Sign in to saveAlso known as EPM1B, RILP, prickle planar cell polarity protein 1
Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene.
Gene data
PRICKLE1- Name
- prickle planar cell polarity protein 1
- Type
- protein-coding
- Aliases
- EPM1B, RILP
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009].
via MyGene.info
Gene · Ensembl
prickle planar cell polarity protein 1
- Symbol
- PRICKLE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:42,456,753-42,590,355
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 17686
- exact match
- identifiers.org/ncbigene/144165
- genomic end
- 42984157
- genomic start
- 42456757
- cytogenetic location
- 12q12
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Function
- References
- Further reading
Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene.
==Function==