Structure via PubChem · Public domain (PubChem)
primidone
Sign in to saveAlso known as Mysoline®, 5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione, 2-deoxyphenobarbital, 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione, Desoxyphenobarbital, Primidon, Primaclone
Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.
Key facts
- Drug.width2
- 150
- Drug.width
- 150
- Drug.Verifiedfields
- changedb
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462079478
- Drug.image
- Primidone.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Primidone ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Lepsiral, Mysoline, Resimatil, others
- Drug.MedlinePlus
- a682023
- Drug.DailyMedID
- Primidone
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Anticonvulsant, barbiturate
- Drug.ATC_prefix
- N03
- Drug.ATC_suffix
- AA03
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C12H14N2O2
- Molecular weight
- 218.25 g/mol
- IUPAC name
- 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
- SMILES
- CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
- InChIKey
- DQMZLTXERSFNPB-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 58.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
1,991 papers- Primidone Intolerance in Essential tremor: Is it More than Just Age?Tremor and other hyperkinetic movements (New York, N.Y.) · 2021
- [Primidone].Nihon rinsho. Japanese journal of clinical medicine · 1995
- Acute primidone intoxication.Archives of neurology · 1974
- Is primidone the drug of choice for epileptic patients with QT-prolongation? A comprehensive analysis of literature.Seizure · 2006
- Primidone-induced "uraemic flap".Lancet (London, England) · 1979
via PubMed
~24 min read
Encyclopedic overview
17 sectionsContents
- Medical uses
- Epilepsy
- Essential tremor
- Psychiatric disorders
- Adverse effects
- Overdose
- Interactions
- Mechanism of action
- Pharmacokinetics
- History
- Association with megaloblastic anemia
- Successive anticonvulsants
- Available forms
- Veterinary uses
- References
- Further reading
- External links
Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.
Its common side effects include sleepiness, poor coordination, nausea, and loss of appetite. Severe side effects may include suicide and psychosis. Use during pregnancy may result in harm to the fetus. Primidone is an anticonvulsant of the barbiturate class; however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. The drug’s other active metabolite is Phenylethylmalonamide (PEMA).
Excerpted from Wikipedia’s “primidone” article, available under the CC BY-SA 4.0 licence.