primidone

Also known as Mysoline®, 5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione, 2-deoxyphenobarbital, 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione, Desoxyphenobarbital, Primidon, Primaclone

Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.

Key facts

Drug.width2: 150
Drug.width: 150
Drug.Verifiedfields: changedb
Drug.Watchedfields: changed
Drug.verifiedrevid: 462079478
Drug.image: Primidone.svg
Drug.image_class: skin-invert-image
Drug.image2: Primidone ball-and-stick.png
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Drug.tradename: Lepsiral, Mysoline, Resimatil, others
Drug.MedlinePlus: a682023
Drug.DailyMedID: Primidone
Drug.pregnancy_AU

~24 min read

Article

17 sections

Contents

Medical uses
Epilepsy
Essential tremor
Psychiatric disorders
Adverse effects
Overdose
Interactions
Mechanism of action
Pharmacokinetics
History
Association with megaloblastic anemia
Successive anticonvulsants
Available forms
Veterinary uses
References
Further reading
External links

Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.

Its common side effects include sleepiness, poor coordination, nausea, and loss of appetite. Severe side effects may include suicide and psychosis. Use during pregnancy may result in harm to the fetus. Primidone is an anticonvulsant of the barbiturate class; however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. The drug’s other active metabolite is Phenylethylmalonamide (PEMA).