Structure via PubChem · Public domain (PubChem)
ethotoin
Sign in to saveAlso known as Peganone®, 3-ethyl-5-phenyl-2,4-imidazolidinedione, 1-ethyl-2,5-dioxo-4-phenylimidazolidine, 3-ethyl-5-phenylhydantoin, (+-)-3-ethyl-5-phenylhydantoin, 3-ethyl-5-phenylimidazolidin-2,4-dione, 1-Ethyl-2,5-dioxo-4-phenylimidazolidine, 3-Ethyl-5-phenyl-2,4-imidazolidinedione
Ethotoin (previously marketed as Peganone) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. It is not available in the United States.
Chemical data
- Formula
- C11H12N2O2
- Molecular weight
- 204.22 g/mol
- IUPAC name
- 3-ethyl-5-phenylimidazolidine-2,4-dione
- SMILES
- CCN1C(=O)C(NC1=O)C2=CC=CC=C2
- InChIKey
- SZQIFWWUIBRPBZ-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 49.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1957
- Admin. routes
- oral
- Indications
- epilepsy, Seizure
via ChEMBL · EBI
Research
48 papers- Nonlinear ethotoin kinetics.Clinical pharmacology and therapeutics · 1983
- ETHOTOIN.Journal of the American Medical Association · 1958
- Dose-dependent kinetics of ethotoin in man.Clinical and experimental pharmacology & physiology · 1975
- Ethotoin in seizures of childhood and adolescence.Neurology · 1984
- Enantioselective pharmacokinetics of ethotoin in humans following single oral doses of the racemate.Chirality · 1992
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 204.09
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₁H₁₂N₂O₂
- subject has role
- anticonvulsant agent
- medical condition treated
- epilepsy
- World Health Organisation international non-proprietary name
- ethotoin
- canonical SMILES
- CCN1C(=O)C(NC1=O)C2=CC=CC=C2
- defined daily dose
- 2.5
- Commons category
- Ethotoin
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Mechanism of action
- Approval history
- Indications and usage
- Dosing
- Side effects
- Chemistry
- References
Ethotoin (previously marketed as Peganone) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. It is not available in the United States.
==Mechanism of action== The mechanism of action of ethotoin is similar to that of phenytoin.
Excerpted from Wikipedia’s “ethotoin” article, available under the CC BY-SA 4.0 licence.