PRPF8
Sign in to saveAlso known as pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
Gen der Spezies Homo sapiens
Gene data
PRPF8- Name
- pre-mRNA processing factor 8
- Type
- protein-coding
- Position
- 1,650,624–1,684,909 (−)
- Aliases
- HPRP8, PRP8, PRPC8, RP13, SNRNP220
- Ensembl
- ENSG00000274442
- RefSeq RNA
- NM_006445.4, XM_024450537.2, XM_054314722.1, XM_054329197.1
- RefSeq protein
- NP_006436.3, XP_024306305.1, XP_054170697.1, XP_054185172.1
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
spliceosomal tri-snRNP complex assemblyspliceosomal tri-snRNP complex assemblyRNA splicing, via transesterification reactionsspliceosomal snRNP assemblyspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)mRNA splicing, via spliceosomemRNA splicing, via spliceosomemRNA splicing, via spliceosome
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pre-mRNA processing factor 8
- Symbol
- PRPF8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR17_1_CTG2:80,657-114,910
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PRPF8 PDB 3E9L.png
Show 7 more facts
- HomoloGene ID
- 4706
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10594
- chromosome
- human chromosome 17
- genomic start
- 1553923
- genomic end
- 1684867
- cytogenetic location
- 17p13.3
Sources (4)
via Wikidata · CC0