catenin beta 1
Sign in to saveAlso known as catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa, Beta-catenin, CTNNB1, CTNNB1 protein, human
mammalian protein found in Homo sapiens
In the Vinony graph
Vinony's link graph records 590 inbound references to catenin beta 1, and connects out to myocardium, APC and hair keratin.
It sits within the topics Armadillo-repeat-containing proteins, Catenins and Genes on human chromosome 3.
Vinony links it to 19 Wikipedia language editions.
Protein · UniProt
Catenin beta-1
- Gene
- CTNNB1
- Organism
- Homo sapiens (Human)
- Length
- 781 aa
- Molecular mass
- 85,497 Da
- Evidence
- 1: Evidence at protein level
Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt l…
Swiss-Prot (reviewed) · via UniProt
Research
7,104 papers- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities.Signal transduction and targeted therapy · 2022
- The origin of hepatocellular carcinoma depends on metabolic zonation.Science (New York, N.Y.) · 2026
- Modulating β-catenin homeostasis for cancer therapy.Trends in cancer · 2024
- beta-catenin signaling and cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 1999
- Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.Radiology · 2025
via PubMed
Clinical Trials
7 registered- PHASE1/PHASE2RECRUITINGSafety and Efficacy of Tegavivint in Patients With Metastatic Colorectal CarcinomaHonorHealth Research Institute · NCT07463599
- COMPLETEDHyperekplexia in Patients With CTNNB1 MutationCentre Hospitalier Universitaire de Saint Etienne · NCT05168969
- PHASE1/PHASE2RECRUITINGFOG-001 in Locally Advanced or Metastatic Solid TumorsParabilis Medicines, Inc. · NCT05919264
- COMPLETEDGenotype-phenotype Correlations in Children and Adults With CTNNB1 MutationUniversity Medical Centre Ljubljana · NCT04812119
- RECRUITINGOnline Study of People Who Have Genetic Changes and Features of Autism: Simons SearchlightSimons Searchlight · NCT01238250
- RECRUITINGCTNNB1 Neurodevelopmental Syndrome - Natural History StudyUniversity Medical Centre Ljubljana · NCT07167732
Wikidata facts
Show 3 more facts
- exact match
- identifiers.org/uniprot:P35222
- found in taxon
- Homo sapiens
- Commons category
- Beta-Catenin
via Wikidata · CC0