catenin beta 1
Sign in to saveAlso known as catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa, Beta-catenin, CTNNB1, CTNNB1 protein, human
mammalian protein found in Homo sapiens
Protein · UniProt
Catenin beta-1
- Gene
- CTNNB1
- Organism
- Homo sapiens (Human)
- Length
- 781 aa
- Molecular mass
- 85,497 Da
- Evidence
- 1: Evidence at protein level
Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt l…
Swiss-Prot (reviewed) · via UniProt
Research
7,104 papers- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities.Signal transduction and targeted therapy · 2022
- The origin of hepatocellular carcinoma depends on metabolic zonation.Science (New York, N.Y.) · 2026
- Modulating β-catenin homeostasis for cancer therapy.Trends in cancer · 2024
- beta-catenin signaling and cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 1999
- Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.Radiology · 2025
via PubMed
Clinical Trials
7 registered- PHASE1/PHASE2RECRUITINGSafety and Efficacy of Tegavivint in Patients With Metastatic Colorectal CarcinomaHonorHealth Research Institute · NCT07463599
- COMPLETEDHyperekplexia in Patients With CTNNB1 MutationCentre Hospitalier Universitaire de Saint Etienne · NCT05168969
- PHASE1/PHASE2RECRUITINGFOG-001 in Locally Advanced or Metastatic Solid TumorsParabilis Medicines, Inc. · NCT05919264
- COMPLETEDGenotype-phenotype Correlations in Children and Adults With CTNNB1 MutationUniversity Medical Centre Ljubljana · NCT04812119
- RECRUITINGOnline Study of People Who Have Genetic Changes and Features of Autism: Simons SearchlightSimons Searchlight · NCT01238250
- RECRUITINGCTNNB1 Neurodevelopmental Syndrome - Natural History StudyUniversity Medical Centre Ljubljana · NCT07167732
Wikidata facts
Show 3 more facts
- exact match
- identifiers.org/uniprot:P35222
- found in taxon
- Homo sapiens
- Commons category
- Beta-Catenin
via Wikidata · CC0