Structure via PubChem · Public domain (PubChem)
puerarin
Sign in to saveAlso known as 8-(β-D-glucopyranosyl)-4′,7-dihydroxyisoflavone
Puerarin, one of several known isoflavones, is found in a number of plants and herbs, such as the root of the kudzu plant.
Chemical data
- Formula
- C21H20O9
- Molecular weight
- 416.4 g/mol
- IUPAC name
- 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
- SMILES
- C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
- InChIKey
- HKEAFJYKMMKDOR-VPRICQMDSA-N
- XLogP
- 0
- Polar surface area
- 157 Ų
- H-bond donors
- 6
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, rheumatoid arthritis, alcohol abuse
via ChEMBL · EBI
Research
2,271 papers- Puerarin: a review of pharmacological effects.Phytotherapy research : PTR · 2014
- Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
- Puerarin prevents sepsis-associated encephalopathy by regulating the AKT1 pathway in microglia.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023
- Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages.International journal of molecular sciences · 2023
- Puerarin ameliorates metabolic dysfunction-associated fatty liver disease by inhibiting ferroptosis and inflammation.Lipids in health and disease · 2023
via PubMed
Wikidata facts
- Mass
- 416.11073222
Show 5 more facts
- canonical SMILES
- C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
- chemical formula
- C₂₁H₂₀O₉
- found in taxon
- Trifolium pratense
- subject has role
- vasodilator agent
- isomeric SMILES
- C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- List of plants that contain the chemical
- Notes and references
Puerarin, one of several known isoflavones, is found in a number of plants and herbs, such as the root of the kudzu plant.
Puerarin is the 8-C-glucoside of daidzein.
Excerpted from Wikipedia’s “puerarin” article, available under the CC BY-SA 4.0 licence.