CD22 molecule
Sign in to saveAlso known as BL-CAM, sialic acid-binding Ig-like lectin 2, CD22, B-lymphocyte cell adhesion molecule, B-cell receptor CD22, CD22 antigen, T-cell surface antigen Leu-14, Siglec-2
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
Research
1,180 papers- Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
- CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.Pharmacological research · 2023
- CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.Nature · 2019
- CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder.Journal of neuroinflammation · 2024
- CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.Nature medicine · 2018
via PubMed
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Article
12 sectionsContents
- Structure
- Extracellular part
- Trans ligands
- BCR signaling
- Inhibitory role
- Activation role
- Autoimmunity
- As a drug target
- Inotuzumab
- Interactions
- References
- External links
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains. alt=|center|thumb|image of microglia