RASGRP1
Sign in to saveAlso known as CALDAG-GEFI, CALDAG-GEFII, RASGRP, hRasGRP1, RAS guanyl releasing protein 1, IMD64
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
Gene data
RASGRP1- Name
- RAS guanyl releasing protein 1
- Type
- protein-coding
- Position
- 38,488,103–38,565,575 (−)
- Aliases
- CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP
- Ensembl
- ENSG00000172575
- RefSeq RNA
- NM_001128602.2, NM_001306086.2, NM_005739.4, XM_047432073.1, XM_047432074.1
- RefSeq protein
- NP_001122074.1, NP_001293015.1, NP_005730.2, XP_047288029.1, XP_047288030.1
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4195
- exact match
- identifiers.org/ncbigene/10125
- genomic end
- 38857776
- genomic start
- 38780304
- cytogenetic location
- 15q14
via Wikidata · CC0
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Article
6 sectionsContents
- Function
- Gene
- Clinical significance
- References
- Further reading
- External links
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
== Function ==