File:Reye's_syndrome_liver-histology.jpg · Wikimedia Commons · See Wikimedia Commons
Reye syndrome
Sign in to saveAlso known as Reye's syndrome (disorder), Reye's syndrome
syndrome characterized by acute brain damage and liver function problems
Key facts
- Other names
- Reye's syndrome
- Pronunciation
- / r aɪ ˈ s ɪ n d r oʊ m / rye SIN -drohm
- Specialty
- Pediatrics
- Symptoms
- Vomiting , personality changes, confusion, seizures , loss of consciousness
- Complications
- Persistent vegetative state , coma
- Causes
- Unknown
- Risk factors
- Aspirin use in children, viral infection
- Treatment
- Supportive care
- Medication
- Mannitol
- Frequency
- Less than one in a million children a year
- Deaths
- ~30% chance of death
via Wikipedia infobox
Research
2,136 papers- Aspirin and Reye syndrome: a review of the evidence.Paediatric drugs · 2007
- Reye syndrome.Neurologic clinics · 1985
- Reye's syndrome.Advances in pediatrics · 1976
- Reye syndrome.The American journal of nursing · 2003
- Reye's syndrome.Medicine, science, and the law · 1997
via PubMed
Wikidata facts
- Subclass of
- disease
- Image
- Reye's syndrome liver-histology.jpg
Show 8 more facts
- Commons category
- Reye's syndrome
- NCI Thesaurus ID
- C34983
- health specialty
- neurology
- drug or therapy used for treatment
- perphenazine
- exact match
- www.orpha.net/ORDO/Orphanet_3096
- on focus list of Wikimedia project
- WikiProject Medicine
- ICD-9-CM
- 331.81
- has cause
- aspirin
Sources (6)
via Wikidata · CC0
~11 min read
Encyclopedic overview
Reye syndrome is a rapidly worsening brain disease. Signs and symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. While liver toxicity typically occurs in the syndrome, jaundice usually does not. Death occurs in 20–40% of those affected with Reye syndrome, and about a third of those who survive are left with a significant degree of brain damage.
The cause of Reye syndrome is unknown. It usually begins shortly after recovery from a viral infection, such as influenza or chickenpox. About 90% of cases in children are associated with aspirin (acetylsalicylic acid) use. Inborn errors of metabolism are also a risk factor. The syndrome is associated with changes on blood tests such as a high blood ammonia level, low blood sugar level, and prolonged prothrombin time. Often, the liver is enlarged in those who have the syndrome.
Excerpted from Wikipedia’s “Reye syndrome” article, available under the CC BY-SA 4.0 licence.