Structure via PubChem · Public domain (PubChem)
perphenazine
Sign in to saveAlso known as Decentan®, Fentazin®, Trilafon®, Περφαιναζίνη, 4-[3-(2-χλωρο-10Η-φαινοθειαζιν-10-υλ)προπυλ]-1-πιπεραζινοαιθανόλη, 4-[3-(2-χλωροφαινοθειαζιν-10-υλ)προπυλ]-1-πιπεραζινοαιθανόλη, Περφεναζίνη, γ-(4-(βήτα-υδροξυαιθυλ)πιπεραζιν-1-υλ)προπυλ-2-χλωροφαινοθειαζίνη
Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades.
Chemical data
- Formula
- C21H26ClN3OS
- Molecular weight
- 404 g/mol
- IUPAC name
- 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
- SMILES
- C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
- InChIKey
- RGCVKNLCSQQDEP-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 55.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,086 papers- Perphenazine for schizophrenia.The Cochrane database of systematic reviews · 2015
- Perphenazine for schizophrenia.The Cochrane database of systematic reviews · 2005
- Adding perphenazine to increase effectiveness of standard glioblastoma chemoirradiation.Journal of B.U.ON. : official journal of the Balkan Union of Oncology · 2020
- Perphenazine modified pillar[5]arene based nano-assemblies for synergistic photothermal and photodynamic cancer therapy.Chemical communications (Cambridge, England) · 2024
- Depot perphenazine decanoate and enanthate for schizophrenia.The Cochrane database of systematic reviews · 2005
via PubMed
Wikidata facts
- Mass
- 403.148511
Show 5 more facts
- chemical formula
- C₂₁H₂₆ClN₃OS
- Commons category
- Perphenazine
- canonical SMILES
- C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
- World Health Organisation international non-proprietary name
- perphenazine
- defined daily dose
- 16
Sources (7)
via Wikidata · CC0
~12 min read
Article
10 sectionsContents
- Medical uses
- Effectiveness
- Side effects
- Discontinuation
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Formulations
- Interactions
- References
Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades.
Perphenazine is roughly ten times as potent as chlorpromazine at the dopamine-2 (D2) receptor; thus perphenazine is considered a medium-potency antipsychotic.