RFC5

Name

replication factor C subunit 5

Type

protein-coding

Position

118,013,588–118,033,545 (+)

Aliases

RFC36

Ensembl

ENSG00000111445

RefSeq RNA

NM_001130112.4, NM_001130113.3, NM_001206801.3, NM_001346815.2, NM_007370.7

RefSeq protein

NP_001123584.1, NP_001123585.1, NP_001193730.1, NP_001333744.1, NP_031396.1

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

via MyGene.info

Gene · Ensembl

replication factor C subunit 5

Symbol

RFC5

Biotype

Protein coding

Organism

Homo sapiens

Location

12:118,013,588-118,033,545

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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