RFC4
Sign in to saveAlso known as A1, RFC37, replication factor C subunit 4
Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.
Gene data
RFC4- Name
- replication factor C subunit 4
- Type
- protein-coding
- Position
- 186,789,866–186,807,058 (−)
- Aliases
- A1, MRMNS, RFC37
- Ensembl
- ENSG00000163918
- RefSeq RNA
- NM_002916.5, NM_181573.3
- RefSeq protein
- NP_002907.1, NP_853551.1
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
replication factor C subunit 4
- Symbol
- RFC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:186,789,866-186,807,058
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.
== Function ==
Excerpted from Wikipedia’s “RFC4” article, available under the CC BY-SA 4.0 licence.