BRD4

Also known as CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4

Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene.

Gene data

BRD4

Name: bromodomain containing 4
Type: protein-coding
Position: 15,235,519–15,332,547 (−)
Aliases: CAP, CDLS6, FSHRG4, HUNK1, HUNKI, MCAP
Ensembl: ENSG00000141867
RefSeq RNA: NM_001330384.2, NM_001379291.1, NM_001379292.1, NM_014299.3, NM_058243.3
RefSeq protein: NP_001317313.1, NP_001366220.1, NP_001366221.1, NP_055114.1, NP_490597.1

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

Pathways

Adaptive Immune System Disease Immune System Regulation of T cell activation by CD28 family Co-inhibition by PD-1 Infectious disease Potential therapeutics for SARS SARS-CoV Infections Viral Infection Pathways Regulation of PD-L1(CD274) expression

via MyGene.info

Gene · Ensembl

bromodomain containing 4

Symbol: BRD4
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:15,235,519-15,332,547
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

7 sections

Contents

Structure
Function
Role in cancer
Interactions
References
Further reading
External links

Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene.

BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues. BRD4 also has an extended C-terminal domain with little sequence homology to other BET family members.

Excerpted from Wikipedia’s “BRD4” article, available under the CC BY-SA 4.0 licence.