RFX6
Sign in to saveAlso known as MTCHRS, MTFS, RFXDC1, dJ955L16.1, regulatory factor X6
Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.
Gene data
RFX6- Name
- regulatory factor X6
- Type
- protein-coding
- Aliases
- MTCHRS, MTFS, RFXDC1, dJ955L16.1
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010].
via MyGene.info
Gene · Ensembl
regulatory factor X6
- Symbol
- RFX6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:116,877,212-116,933,069
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 18318
- exact match
- identifiers.org/ncbigene/222546
- genomic end
- 116932161
- genomic start
- 117198375
- cytogenetic location
- 6q22.1
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.
== Function ==