RGS1

Also known as 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, regulator of G protein signaling 1

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

Gene data

RGS1

Name: regulator of G protein signaling 1
Type: protein-coding
Position: 192,575,763–192,580,037 (+)
Aliases: 1R20, BL34, HEL-S-87, IER1, IR20
Ensembl: ENSG00000090104
RefSeq RNA: NM_002922.4
RefSeq protein: NP_002913.3

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008].

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events Myometrial relaxation and contraction pathways

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 1

Symbol: RGS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:192,575,763-192,580,037
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

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Contents

References
Further reading

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

Excerpted from Wikipedia’s “RGS1” article, available under the CC BY-SA 4.0 licence.