RGS4

Also known as AA004315, AA597169, ESTM48, ESTM50, RGP4, SCZD9, regulator of G-protein signaling 4

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.

Gene data

RGS4

Name: regulator of G protein signaling 4
Type: protein-coding
Position: 163,068,775–163,076,802 (+)
Aliases: RGP4, SCZD9
Ensembl: ENSG00000117152
RefSeq RNA: NM_001102445.3, NM_001113380.1, NM_001113381.1, NM_005613.6
RefSeq protein: NP_001095915.1, NP_001106851.1, NP_001106852.1, NP_005604.1

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].