RGS7

Also known as regulator of G protein signaling 7

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

Gene data

RGS7

Name: regulator of G protein signaling 7
Type: protein-coding
Position: 240,767,636–241,357,374 (−)
Ensembl: ENSG00000182901
RefSeq RNA: NM_001282773.2, NM_001282775.2, NM_001282778.2, NM_001350113.2, NM_001350114.2
RefSeq protein: NP_001269702.1, NP_001269704.1, NP_001269707.1, NP_001337042.1, NP_001337043.1

Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling Chaperonin-mediated protein folding Protein folding Metabolism of proteins G alpha (i) signalling events

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 7

Symbol: RGS7
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:240,767,636-241,357,374
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein RGS7 PDB 2a72.png

Show 9 more facts

HomoloGene ID: 2193
exact match: identifiers.org/ncbigene/6000
genetic association: obesity
found in taxon: Homo sapiens
genomic end: 241357374
genomic start: 240767636
chromosome: human chromosome 1
cytogenetic location: 1q43|1q23.1
Commons category: Regulator of G-protein signaling 7, RGS7

Sources (6)

via Wikidata · CC0

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Encyclopedic overview

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Contents

Interactions
References
Further reading

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.

Excerpted from Wikipedia’s “RGS7” article, available under the CC BY-SA 4.0 licence.