RNF2

Also known as BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Gene data

RNF2

Name: ring finger protein 2
Type: protein-coding
Aliases: BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B, RING2

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image: E3 ubiquitin-protein ligase RING2 within the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b - 2CKL.png

Show 5 more facts

HomoloGene ID: 2199
exact match: identifiers.org/ncbigene/6045
genomic end: 185102603
genomic start: 185045526
cytogenetic location: 1q25.3

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E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with an ubiquitin-conjugating enzyme UBE2K, and possess ubiquitin ligase activity.