UBE2K

Also known as E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.

Gene data

UBE2K

Name: ubiquitin conjugating enzyme E2 K
Type: protein-coding
Aliases: E2-25K, HIP2, HYPG, LIG, UBC1

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image: Protein HIP2 PDB 1yla.png

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HomoloGene ID: 3903
genomic start: 39698109
exact match: identifiers.org/ncbigene/3093
genomic end: 39784412
cytogenetic location: 4p14

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Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.