UBE2K
Sign in to saveAlso known as E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.
In the Vinony graph
Vinony's link graph records 113 inbound references to UBE2K, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 4.
Vinony links it to 6 Wikipedia language editions.
Gene data
UBE2K- Name
- ubiquitin conjugating enzyme E2 K
- Type
- protein-coding
- Position
- 39,697,879–39,782,792 (+)
- Aliases
- E2-25K, HIP2, HYPG, LIG, UBC1
- Ensembl
- ENSG00000078140
- RefSeq RNA
- NM_001111112.2, NM_001111113.2, NM_001312646.2, NM_001312647.2, NM_001312648.2
- RefSeq protein
- NP_001104582.1, NP_001104583.1, NP_001299575.1, NP_001299576.1, NP_001299577.1
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
ubiquitin conjugating enzyme E2 K
- Symbol
- UBE2K
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:39,697,879-39,782,792
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HIP2 PDB 1yla.png
Show 7 more facts
- HomoloGene ID
- 3903
- genomic start
- 39698109
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3093
- genomic end
- 39784412
- chromosome
- human chromosome 4
- cytogenetic location
- 4p14
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.
Excerpted from Wikipedia’s “UBE2K” article, available under the CC BY-SA 4.0 licence.