sebelipase alfa
Sign in to saveAlso known as Kanuma
recombinant form of the enzyme lysosomal acid lipase
In the Vinony graph
Within Vinony's link graph, sebelipase alfa is referenced by 118 other articles, and connects out to United States Food and Drug Administration, laronidase and Arylsulfatase B.
It sits within the topics Biopharmaceuticals, Chemicals that do not have a ChemSpider ID assigned and Drugs developed by AstraZeneca.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Enzyme
- First approval
- 2015
- Admin. routes
- parenteral
- Indications
- Wolman disease, cholesteryl ester storage disease, lysosomal acid lipase deficiency, inborn errors of metabolism
via ChEMBL · EBI
Medication
- Brand names
- Kanuma
- Drug class
- Enzymes
- Active ingredients
- sebelipase alfa
- Dosage form
- Injection
Sources: openFDA · RxNorm (NLM). Not medical advice.
Clinical Trials
7 registered- PHASE2COMPLETEDExtension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT01488097
- NO_LONGER_AVAILABLEAn Expanded Access Protocol for Sebelipase Alfa for Patients With Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT02376751
- PHASE2/PHASE3COMPLETEDSafety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT01371825
- PHASE3COMPLETEDAcid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT01757184
- PHASE1/PHASE2COMPLETEDSafety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT01307098
- PHASE2TERMINATEDClinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase DeficiencyAlexion Pharmaceuticals, Inc. · NCT02193867
Wikidata facts
- Instance of
- enzyme
- Subclass of
- medication
- Mass
- 43003.4822
Show 3 more facts
- World Health Organisation international non-proprietary name
- sebelipase alfa
- chemical formula
- C₁₉₆₈H₂₉₄₅N₅₀₇O₅₅₁S₁₅
- defined daily dose
- 5
via Wikidata · CC0