secreted phosphoprotein 1
Sign in to saveAlso known as osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 variant 6, early T-lymphocyte activation 1, uropontin, urinary stone protein, SPP1, SPP-1, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts.
Key facts
- Protein family.Symbol
- Osteopontin
- Protein family.Name
- Osteopontin
- Protein family.caption
- crystal structure of anti-osteopontin antibody 23c3 in complex with w43a mutated epitope peptide
- Protein family.Pfam
- PF00865
- Protein family.InterPro
- IPR002038
- Protein family.PROSITE
- PDOC00689
via Wikipedia infobox
Protein · UniProt
Osteopontin
- Gene
- SPP1
- Organism
- Homo sapiens (Human)
- Length
- 314 aa
- Molecular mass
- 35,423 Da
- Evidence
- 1: Evidence at protein level
Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction
Swiss-Prot (reviewed) · via UniProt
Research
14,302 papersvia PubMed
Clinical Trials
17 registered- COMPLETEDOsteopontin in Metastatic Breast Cancer PatientsMansoura University · NCT04274504
- COMPLETEDSerum Biomarkers in Diagnosis of MesotheliomaEskisehir Osmangazi University · NCT02029105
- COMPLETEDHeavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD)Medical University of Vienna · NCT02159235
- PHASE2COMPLETEDNatalizumab Treatment of Progressive Multiple SclerosisRigshospitalet, Denmark · NCT01077466
- PHASE2COMPLETEDCyclic Oral Methylprednisolone Trial in Multiple SclerosisRigshospitalet, Denmark · NCT01305837
- UNKNOWNMesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial HyperplasiaUniversity Hospital, Caen · NCT00899613
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular space
- exact match
- purl.uniprot.org/uniprot/P10451
- found in taxon
- Homo sapiens
via Wikidata · CC0
~24 min read
Encyclopedic overview
24 sectionsContents
- Structure
- Isoforms
- Tissue distribution
- Regulation
- Function
- Apoptosis
- Biomineralization
- Bone remodeling
- Cell activation
- Chemotaxis
- Immune system
- Clinical significance
- Autoimmune diseases
- Allergy and asthma
- Colitis
- Cancer
- Heart failure
- Parkinson's disease
- Muscle disease and injury
- Hip osteoarthritis
- Fertilized egg implantation
- References
- Further reading
- External links
Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts.
The prefix osteo- indicates that the protein is expressed in bone, although it is also expressed in other tissues. The suffix -pontin is derived from "pons," the Latin word for bridge, and signifies osteopontin's role as a linking protein. Osteopontin is an extracellular structural protein and therefore an organic component of bone.
Excerpted from Wikipedia’s “secreted phosphoprotein 1” article, available under the CC BY-SA 4.0 licence.