SELENOT

Name

selenoprotein T

Type

protein-coding

Position

150,602,875–150,631,370 (+)

Aliases

SELT

Ensembl

ENSG00000198843

RefSeq RNA

NM_016275.5

RefSeq protein

NP_057359.2

This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017].

via MyGene.info

Gene · Ensembl

selenoprotein T

Symbol

SELENOT

Biotype

Protein coding

Organism

Homo sapiens

Location

3:150,602,875-150,631,370

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0