SETDB1
Sign in to saveAlso known as ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1
Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.
Gene data
SETDB1- Name
- SET domain bifurcated histone lysine methyltransferase 1
- Type
- protein-coding
- Position
- 150,926,263–150,964,748 (+)
- Aliases
- ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
- Ensembl
- ENSG00000143379
- RefSeq RNA
- NM_001145415.2, NM_001243491.2, NM_001366417.1, NM_001366418.1, NM_001393958.1
- RefSeq protein
- NP_001138887.1, NP_001230420.1, NP_001353346.1, NP_001353347.1, NP_001380887.1
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
SET domain bifurcated histone lysine methyltransferase 1
- Symbol
- SETDB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:150,926,263-150,964,748
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI