TRIM28
Sign in to saveAlso known as KAP1, PPP1R157, RNF96, TF1B, TIF1B, tripartite motif containing 28, TIF1beta
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the TRIM28 gene.
Gene data
TRIM28- Name
- tripartite motif containing 28
- Type
- protein-coding
- Position
- 58,543,740–58,550,773 (+)
- Aliases
- KAP1, PPP1R157, RNF96, TF1B, TIF1B, TIF1beta, WT7
- Ensembl
- ENSG00000130726
- RefSeq RNA
- NM_005762.3
- RefSeq protein
- NP_005753.1
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
tripartite motif containing 28
- Symbol
- TRIM28
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:58,543,740-58,550,773
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
13 sectionsContents
- Function
- Cellular differentiation and proliferation
- Transcriptional regulation
- DNA damage repair response
- Apoptosis
- Clinical significance
- Role in the establishment of viral latency
- Manipulations and potential for future treatment
- Interactions
- See also
- References
- Further reading
- External links
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the TRIM28 gene.
== Function == The protein encoded by this gene mediates transcriptional regulation by interacting with the Krüppel-associated box (KRAB) repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. TRIM28 is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING finger domain, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM28 additionally possesses a domain that interacts with heterochromatin protein 1 (HP1) and a bromodomain capable of recognizing acetylated lysine residues in other proteins.
Excerpted from Wikipedia’s “TRIM28” article, available under the CC BY-SA 4.0 licence.