SETDB1
Sign in to saveAlso known as ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1
gene umano
Gene data
SETDB1- Name
- SET domain bifurcated histone lysine methyltransferase 1
- Type
- protein-coding
- Position
- 150,926,263–150,964,748 (+)
- Aliases
- ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21
- Ensembl
- ENSG00000143379
- RefSeq RNA
- NM_001145415.2, NM_001243491.2, NM_001366417.1, NM_001366418.1, NM_001393958.1
- RefSeq protein
- NP_001138887.1, NP_001230420.1, NP_001353346.1, NP_001353347.1, NP_001380887.1
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
DNA methylation-dependent constitutive heterochromatin formationDNA methylation-dependent constitutive heterochromatin formationnegative regulation of gene expressionnegative regulation of gene expressionheterochromatin organizationheterochromatin organizationtransposable element silencing by heterochromatin formationtransposable element silencing by heterochromatin formation
Molecular function
Cellular component
Pathways
Lysine degradation - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Epigenetic regulation of gene expressionEpigenetic regulation of gene expressionPKMTs methylate histone lysinesChromatin modifying enzymesChromatin organizationGene expression (Transcription)Gene expression (Transcription)Regulation of endogenous retroelements
via MyGene.info
Gene · Ensembl
SET domain bifurcated histone lysine methyltransferase 1
- Symbol
- SETDB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:150,926,263-150,964,748
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 32157
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9869
- genomic end
- 150937213
- genomic start
- 150898739
- chromosome
- human chromosome 1
- cytogenetic location
- 1q21.3
Sources (3)
via Wikidata · CC0