SH2B2
Sign in to saveAlso known as APS, SH2B adaptor protein 2
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
In the Vinony graph
Vinony's link graph records 7 inbound references to SH2B2, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 7.
Vinony links it to 5 Wikipedia language editions.
Gene data
SH2B2- Name
- SH2B adaptor protein 2
- Type
- protein-coding
- Position
- 102,284,995–102,321,712 (+)
- Aliases
- APS
- Ensembl
- ENSG00000160999
- RefSeq RNA
- NM_001359228.2, NM_001359229.2, NM_001359230.2, NM_001359231.2, NM_001393990.3
- RefSeq protein
- NP_001346157.1, NP_001346158.1, NP_001346159.1, NP_001346160.1, NP_001380919.2
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SH2B adaptor protein 2
- Symbol
- SH2B2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:102,284,995-102,321,712
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SH2B2 PDB 1q2h.png
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 10309
- exact match
- identifiers.org/ncbigene/10603
- chromosome
- human chromosome 7
- genomic start
- 101928405
- genomic end
- 101962178
- cytogenetic location
- 7q22.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
== Function ==
Excerpted from Wikipedia’s “SH2B2” article, available under the CC BY-SA 4.0 licence.