NFIX
Sign in to saveAlso known as MRSHSS, NF1A, SOTOS2, nuclear factor I X, NF1-X, NF-I/X, CTF, MALNS
Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.
Gene data
NFIX- Name
- nuclear factor I X
- Type
- protein-coding
- Position
- 12,995,401–13,098,796 (+)
- Aliases
- CTF, MALNS, MRSHSS, NF-I/X, NF1-X, NF1A, SOTOS2
- Ensembl
- ENSG00000008441
- RefSeq RNA
- NM_001271043.2, NM_001271044.3, NM_001365902.3, NM_001365982.2, NM_001365983.2
- RefSeq protein
- NP_001257972.1, NP_001257973.1, NP_001352831.1, NP_001352911.1, NP_001352912.1
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
nuclear factor I X
- Symbol
- NFIX
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:12,995,401-13,098,796
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.
== Interactions == Nfix has been shown to interact with SKI protein and it is also known to interact with AP-1. NFI-X3 has been shown to interact with STAT3.
Excerpted from Wikipedia’s “NFIX” article, available under the CC BY-SA 4.0 licence.