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GeneQ14913261· pop 5· linked from 15 articles

SKI

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Also known as SKI proto-oncogene, SGS, SKV

Gen der Spezies Homo sapiens

In the Vinony graph

Within Vinony's link graph, SKI is referenced by 15 other articles, and connects out to PubMed, Ensembl genome database project and Wikidata.

Vinony files it under Genes on human chromosome 1 and Oncogenes.

Its subject is documented across 5 Wikipedia language editions.

Gene data

SKI

Name: SKI proto-oncogene
Type: protein-coding
Position: 2,227,388–2,310,213 (+)
Aliases: SGS, SKV
Ensembl: ENSG00000157933
RefSeq RNA: NM_003036.4, XM_005244775.4, XM_005244776.5, XM_017002128.2, XM_047428466.1
RefSeq protein: NP_003027.1, XP_005244832.1, XP_005244833.1, XP_016857617.1, XP_047284422.1

This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II neural tube closure lens morphogenesis in camera-type eye transforming growth factor beta receptor signaling pathway negative regulation of cell population proliferation anterior/posterior axis specification

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding zinc ion binding protein kinase binding protein domain specific binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex transcription regulator complex cytoplasm

Pathways

Signal Transduction Signal Transduction Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex Signaling by BMP Generic Transcription Pathway Generic Transcription Pathway Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Downregulation of SMAD2/3:SMAD4 transcriptional activity

via MyGene.info

Gene · Ensembl

SKI proto-oncogene

Symbol: SKI
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:2,227,388-2,310,213
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein SKI PDB 1mr1.png

Show 7 more facts

HomoloGene ID: 31124
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6497
genomic end: 2310213
genomic start: 2228319
chromosome: human chromosome 1
cytogenetic location: 1p36.33-p36.32

Sources (4)

via Wikidata · CC0

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1 Oncogenes