SMAD5
Sign in to saveAlso known as DWFC, JV5-1, MADH5, SMAD family member 5
Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.
Gene data
SMAD5- Name
- SMAD family member 5
- Type
- protein-coding
- Aliases
- DWFC, JV5-1, MADH5
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
via MyGene.info
Wikidata facts
- Image
- PDB 1khu EBI.jpg
Show 5 more facts
- HomoloGene ID
- 4313
- exact match
- identifiers.org/ncbigene/4090
- genomic end
- 135524435
- genomic start
- 135468534
- cytogenetic location
- 5q31.1
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via Wikidata · CC0
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Article
1 sectionsContents
- References
Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.
SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community. It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.