BMP7
Sign in to saveAlso known as OP-1, bone morphogenetic protein 7
protein-coding gene in the species Homo sapiens
Gene data
BMP7- Name
- bone morphogenetic protein 7
- Type
- protein-coding
- Position
- 57,168,753–57,266,641 (−)
- Aliases
- OP-1
- Ensembl
- ENSG00000101144
- RefSeq RNA
- NM_001719.3
- RefSeq protein
- NP_001710.1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
bone morphogenetic protein 7
- Symbol
- BMP7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:57,168,748-57,266,680
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PDB 1m4u EBI.jpg
Show 5 more facts
- HomoloGene ID
- 20410
- exact match
- identifiers.org/ncbigene/655
- genomic end
- 57266641
- genomic start
- 57168753
- cytogenetic location
- 20q13.31
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